Renal Tubular Transport of Proline, Hydroxyproline, and Glycine in Health and in Familial Hyperprolinemia.
نویسندگان
چکیده
منابع مشابه
Type II hyperprolinemia: a case report.
Hyperprolinemia type II (HP II) is a rare inherited metabolic disease due to the deficiency of pyroline-5-carboxylate dehydrogenase. It is generally believed to be a benign condition although some patients have neurological problems such as refractory convulsions. Here we report a six-year-old girl with HP II who admitted to our hospital with recurrent seizure refractory to multiple antiepilept...
متن کاملLow proline diet in type I hyperprolinaemia.
Harries, J. T., Piesowicz, A. T., Seakins, J. W. T., Francis, D. E. M., and Wolff, 0. H. (1971). Archives of Disease in Childhood, 46, 72. Low proline diet in type I hyperprolinaemia. A diagnosis of Type I hyperprolinaemia was made in a 7-month-old infant who presented with hypocalcaemic convulsions and malabsorption. The plasma levels of proline were grossly raised and the urinary excretion of...
متن کاملOntogeny of iminoglycine transport in mammalian kidney.
Renal tubular absorption of proline, hydroxyproline, and glycine by the newborn of most mammals is inefficient compared to that of the adult. Cortex slices from seven-day-old rat kidney also transport proline and glycine at reduced initial rates compared to mature kidney. Nonetheless, newborn slices achieve higher intracellular concentrations during prolonged incubation; the latter reflects a r...
متن کاملRenal tubular transport of proline, hydroxyproline, and glycine. II. Hydroxy-l-proline as substrate and as inhibitor in vivo.
Renal tubular absorption of the free amino acids L-proline, hydroxy-L-proline, and glycine in man is accomplished by a transport system exhibiting preference for this group of amino acids (1, 2). The characteristics of saturability (for L-proline transport) and selective inhibition between the constituent substrates have been demonstrated for this system in man (1). Studies in vivo in the rat (...
متن کاملRenal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria.
Renal maturation occurs post-natally in many species and reabsorption capacity at birth can vary substantially from the mature kidney. However, little is known regarding the maturation of amino acid transport mechanisms, despite the well-known physiological state of developmental iminoglycinuria. Commonly seen during early infancy, developmental iminoglycinuria is a transient version of the per...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 43 شماره
صفحات -
تاریخ انتشار 1964